At my baby shower for Eli almost two years ago, one of the doctors I work with who is the most practical person I know, got me the most practical gift ever. It was a small tupperware filled with all the things I would need in the middle of the night when the closest drug store is over 30 minutes away. Ever since then, I've adopted this idea to give to all my new mom friends. I simply grab a medium sized plastic tote, and then head for the pharmacy department of Target and go to town! I like to call it my "Midnight Madness Kit!"
Its a great gift because its not gender specific, it isn't something many other people think of, and its a great way to help a new parent stock up on things they may have forgotten or not known to buy. You can also control how much you spend by either making a small kit or a larger kit. Keep in mind, all parents have different view on medicine or nursing, so I always try to steer clear of anything "controversial" unless I already know the mom pretty well. I try not to buy bottles or pacifiers because all parents have their own specific preferences on those as well as any baby formulas or foods.
If you're ever in a bind over what to get a friend for their baby shower, or their registry is thinning out, this is a great one to do! Trust me, they will thank you!